منابع مشابه
GnRH agonist acts as ovarian protection in chemotherapy induced gonadotoxicity: an experiment using a rat model.
To reduce chemotherapy induced gonadotoxicity, co-treatment with gonadotropin releasing hormone against analogue (GnRHa) was tested using rat model. Leuprorelin acetate (Leuplin) with or without cisplatin (CDDP) was given subcutaneously at a dose of 9.4 microg/ml to Wistar strain female rats. The total number of follicles was counted and the maturation of follicles was evaluated at the largest ...
متن کاملHistological Evaluation of Cisplatin-Induced Gonadotoxicity against Murine Visceral Leishmaniasis
Cisplatin had shown anti-leishmanial effect both in vitro and in vivo against murine visceral leishmaniasis. The present study was designed to evaluate the effect of cisplatin on gonads of Leishmania donovani infected BALB/c mice. In drug treated animals, mild reduced spermatogenesis was observed but when antioxidants were supplemented along with cisplatin, the morphological characteristics of ...
متن کاملOxytocin Improves Follicular Reserve in a Cisplatin-Induced Gonadotoxicity Model in Rats
Cisplatin (CP), an antitumor agent, has been shown to cause ovarian injury and dysfunction in both animal and human studies. The present study was conducted to investigate the protective effect of oxytocin (OT) on CP-induced ovarian toxicity in rats. Twenty-one adult female rats were included in the study. Fourteen rats were administered intraperitoneally CP (2 mg/kg/day) twice a week for 5 wee...
متن کاملThe Protective Effects of Naringenin on Testes Gonadotoxicity Induced by Cisplatin in Rats
Cisplatin (CIS) is a highly effective chemotherapeutic agent for the treatment of various types of cancers but causes reproductive toxicity. The present study was aimed to investigate the protective potential of naringenin against CISinduced testicular toxicity in rats.The fertility experiment was done on four groups of male rats. The group 1 was kept as normal control, while the group 2 and 3 ...
متن کاملThe protective effects of acetyl L-carnitine on testis gonadotoxicity induced by Cisplatin in rats.
BACKGROUND Cisplatin, an effective antineoplastic agent, damages normal cells in a manner related to chemotherapy. Acetyl L-carnitine protects cells against mitochondrial and nuclear damage induced by chemotherapy. AIMS Animal experiment. STUDY DESIGN The aim of this study was to examine the protective effects of acetyl L-carnitine on cisplatin-induced gonadotoxicity in testicular structure...
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ژورنال
عنوان ژورنال: Taiwanese Journal of Obstetrics and Gynecology
سال: 2010
ISSN: 1028-4559
DOI: 10.1016/s1028-4559(10)60001-0